Trends of mortality in West Nile Neuroinvasive Disease (WNND) from 2005–2014 in a US hospital cohort. (P1.145)

Objective: To describe outcomes of hospital admissions for West Nile Neuroinvasive Disease (WNND) and the impact of comorbid conditions through a large national dataset. Background: WNND is associated with significant inpatient morbidity and mortality. The Nationwide Inpatient Sample (NIS, AHRQ.gov) is a 20% stratified sample of all US hospital admissions. Design/Methods: In this retrospective study, WNND admissions were identified with a primary diagnosis of 066.41 (encephalitis) and 066.42 (cranial nerve, radiculopathy, other) from 2005 to 2014. Logistic regression was used to examine mortality and the Charlson-Deyo index was used for comorbidities. Age was dichotomized at the median. Results: Males were 63.6% of the cohort and females 36.4% with a median age of 62 (interquartile range 47–72). Mortality was 7.31% for encephalitis (n=875) and 1.5% for other CNS involvement (n=468). Those with encephalitis were more likely to be discharged to a long term care facility (LTCF) (51.3% vs 28.0%). The encephalitis cohort had more comorbidities. The maximum number of cases was in 2012 and there was not a trend in mortality over time. In the logistic regression model, younger patients ( Conclusions: Respiratory failure is associated with increased mortality in patients with WNND encephalitis. The mortality has not change over time. With the high mortality, high discharge rate to LTCF and the lack of treatment, emphasis should be placed on prevention. Disclosure: Dr. Manchanda has nothing to disclose. Dr. Abbasi has nothing to disclose. Dr. Dubinsky has nothing to disclose.