Affinity war: forging immunoglobulin repertoires
Current Opinion in Immunology（2019）
摘要
•Ig tolerance checkpoints themselves may be subject to regulation.•Microbial symbionts influence naïve and experienced Ig repertoires.•Early B lineage polyreactivity may be a deliberate storehouse of innateness.•Somatic hypermutation may expand Ig diversity beyond naïve boundaries.
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