Palladium complexes with 3-methyl-8-thia-1,3-diaza- spiro[4.5]decane-2,4-dione: experimental and theoretical studies

Platinum complexes are a cornerstone of the treatment of various cancers. Their side effects, however, like nephrotoxicity and ototoxicity, have led to the investigation of alternative metal-based anticancer drugs such as palladium complexes, which show promising activities. New cis-palladium complexes with general formulas [PdL2Cl2] and [PdL2Cl4] and ligand 3-methyl-8-thia-1,3-diaza-spiro[4.5]decane-2,4-dione have been synthesized. The structures of the complexes were elucidated by elemental analyses and spectroscopic techniques as well as theoretical methods. Quantum chemical calculations confirm the square planar geometry of Pd(II) and a distorted octahedral coordination of Pd(IV) complexes. The in vitro cytotoxicity-assay results against K-562 and REH cell lines are also reported. [GRAPHICS] .