OSBP-related protein 2 (ORP2): Unraveling its functions in cellular lipid/carbohydrate metabolism, signaling and F-actin regulation

•ORP2 is a mammalian oxysterol-binding protein homologue with affinity for cholesterol, oxysterols and phosphoinositides.•ORP2 is suggested to mediate cholesterol transport to the plasma membrane in exchange for PI4,5P2.•ORP2 knock-out in hepatoma cells resulted in defective triglyceride synthesis and storage.•ORP2 knock-out impaired cellular glucose uptake and metabolism, co-indicent with defective Akt signaling.•ORP2 manipulations impact on F-actin, cell adhesion, migration and proliferation.