P036 LONG-TERM SAFETY AND EFFICACY OF THE ANTI-MUCOSAL ADDRESSIN CELL ADHESION MOLECULE-1 (MADCAM-1) ANTIBODY SHP647 IN ULCERATIVE COLITIS: AN OPEN-LABEL EXTENSION STUDY (TURANDOT II)

Walter Reinisch,William J. Sandborn,Silvio Danese,Xavier Hébuterne,Bruce Salzberg,Maria Klopocka,Dino Tarabar,Tomáš Vanásek,Miloš Greguš,Paul Hellstern,Joo Sum Kim,Miles Sparrow,Kenneth J. Gorelick,Martina Goetsch,Caleb Bliss,Fabio Cataldi,Séverine Vermeire

Gastroenterology（2019）

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摘要

SHP647, a fully human IgG2 monoclonal antibody, binds to human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) to reduce lymphocyte homing to the gastrointestinal tract. SHP647 was well tolerated in a randomized, double-blind phase 2 trial (TURANDOT I; NCT01620255) in patients with ulcerative colitis (UC) over 12 weeks.

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关键词

ulcerative colitis,antibody,long-term,anti-mucosal,open-label

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