Abstract 18832: Trans-ethnic Genome-wide Association Study of Peripheral Artery Disease in the VA Million Veteran Program
Circulation(2017)
摘要
Introduction: Peripheral artery disease (PAD) is the third leading cause of cardiovascular morbidity and mortality worldwide. Despite significant evidence of an underlying genetic component to PAD susceptibility, only a minimal number of loci have reached genome-wide significance (GWS). Previous PAD GWAS have been limited by statistical power due to sample size; the large number of PAD cases within the Million Veteran Program (MVP), a mega-biobank established by the United States Department of Veterans Affairs (VA), is the ideal setting to identify novel risk loci. Hypothesis: DNA sequence variants affect PAD risk. Methods: Using ICD-9 and Current Procedural Terminology (CPT) based algorithms, we identified individuals with and without clinical PAD from among the 353,323 MVP participants genotyped on a customized Affymetrix Axiom Biobank Array. We tested the association of 379,916 directly genotyped DNA sequence variants with clinical PAD separately in participants of European (EUR), African (AFR), and Hi...
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关键词
Peripheral artery disease (PAD),Genome-wide association studies (GWAS),Electronic health records (EHRs),Epidemiology,Vascular disease
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