Lifetime Risk For Cardiovascular Disease Stratified By Fasting Glucose Level

Introduction: Diabetes and insulin resistance are major contributors to atherosclerotic cardiovascular disease (ASCVD) risk, but the lifetime risks (LTR) associated with normoglycemia, impaired fasting glucose (IFG), and diabetes (DM) in middle-aged adults have not been reported. Hypothesis: Higher fasting glucose (FG) category will be associated with a monotonic increase in the LTR for ASCVD. Methods: We pooled data from 7 observational cohorts of US black and white men and women followed from 1960 through 2015. Categories of FG were normoglycemia (u003c100 mg/dl), IFG (100-125 mg/dl), and DM (≥126 mg/dl or use of DM medications). ASCVD was defined as fatal and nonfatal coronary heart disease (CHD) and fatal and nonfatal stroke. Individuals were free of symptomatic ASCVD at index age 55 years. LTR for incident ASCVD after age 55 was estimated according to FG category using a modified Kaplan-Meier survival analysis, adjusted for the competing risk of non-ASCVD death. Results: Our sample included 19630 individ...