The genetics and epigenetics of Neonatal Abstinence Syndrome
Seminars in Fetal and Neonatal Medicine(2019)
摘要
Neonatal abstinence syndrome (NAS) due to in-utero opioid exposure is a growing epidemic with significant variability in clinical presentation and severity. Currently, NAS severity cannot be predicted based on clinical factors alone. To date, small studies have identified genetic variants in opioid receptor and stress response genes that are associated with differences in NAS pharmacologic treatment rates and length of hospitalization. In addition, epigenetic variation in the mu opioid receptor (OPRM1) gene has been associated with differences in NAS hospitalization outcomes. Examination of maternal genetic and epigenetic profiles may assist in prediction of NAS severity. Large-scale genomic studies are needed to elucidate the genetic architecture of and epigenetic modification related to NAS in order to develop more tailored personalized treatments for NAS.
更多查看译文
关键词
Neonatal Abstinence Syndrome (NAS),Neonatal Opioid Withdrawal Syndrome (NOWS),Genetics,Epigenetics
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络