Applying the adverse outcome pathway (AOP) for food sensitization to support in vitro testing strategies
Trends in Food Science & Technology(2019)
摘要
•The AOP for food sensitization helps to implement in vitro testing approaches.•Innate immune mechanisms are easier to address than adaptive response.•No in vitro protocols have been established for investigating IgE-class switching.•Ex vivo strategies are promising to address multiple key events at the same assay.
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关键词
IgE-mediated food allergy,Adverse outcome pathway,In vitro models,Epithelial cells,Dendritic cells,T and B cells
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