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P816 Functional rare variants influence the clinical response to anti-TNF therapy in Crohn’s disease

M Chaparro,A Aterido,I Guerra,M Iborra,J Cabriada,L Bujanda,C Taxonera,V García-Sánchez,I Marín-Jiménez,M Barreiro-de Acosta,I Vera,M Martín-Arranz,B Hernández-Breijo,F Mesonero,L Sempere,F Gomollón,J Hinojosa,A Algaba,B Beltrán,A Rodríguez Pescador,J Banales,D Olivares,P Aguilar-Melero,L Menchén,R Ferreiro-Iglesias, I Blázquez Gómez, B Benitez García,L Guijarro,A C Marín,D Bernardo,S Marsal,A Julia,J P Gisbert

Journal of Crohns & Colitis（2019）

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摘要
Functional rare variants are involved in the response to anti-TNF therapy in CD. Cell-type enrichment analysis suggests that the gut mucosa and CD8 T cells are the main mediators of this response.
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关键词
Crohn’s disease,adalimumab,genes,infliximab,tumor necrosis factor alpha,whole-genome analysis
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