OP10 Systems genomics of ulcerative colitis: combining GWAS and signalling networks for patient stratification and individualised drug targeting in ulcerative colitis

Background The pathogenic signalling pathways of ulcerative colitis (UC) are complex, making patient stratification for optimal therapeutic choices challenging. Disease associated single-nucleotide polymorphisms (SNPs) make the prospect of personalised disease stratification and therapeutics tantalisingly plausible, but forward movement has been difficult. Using systems genomics, we propose a method to identify cohort-specific pathogenic and patient-specific targetable therapeutic pathways. Methods Using UC-associated SNPs from the UKIBD Genetics Consortium and the Broad Institute publicly available datasets, we identified the regulatory effects of UC-associated SNPs by identifying those which were localised in transcription factor-binding sites or miRNA target sites. We developed a workflow, iSNP, to identify these regulatory SNPs and build a UC-interactome …