Identifying Severe Stroke Patients Likely to Benefit From Intervention Despite a Delay of a Day
bioRxiv(2019)
摘要
Background and Purpose: Severe ischemic strokes caused by large vessel occlusion (LVO) are treatable up to 24 hours after onset. But not all patients will benefit either because the infarct enlarges too rapidly or because the patient is not at center that is capable of treatment. The purpose was to find biomarkers that reliably identify patients who are likely to benefit from intervention despite long delays.Methods: Thirty-eight acute ischemic stroke patients with LVO who did not undergo thrombolysis or thrombectomy had serial imaging with MRI at presentation and then at ~12 hours, ~1 day, u0026 ~2 days after onset. Presenting clinical and neuroimaging predictors of a therapeutically auspicious ischemic core size (u003c50 ml) one day after stroke onset were identified. Results: Ischemic core initial growth rate (IGR) was the only independent predictor of functional outcome at 3 months (P=0.002), and a receiver operator characteristics (ROC) analysis revealed that an IGR of u003c5.4 ml/hr had a 95% sensitivity with a low (5.6%) false positive rate for identifying patients who would have an ischemic core of u003c50 ml at one day post ictus. Selection using an initial DWI lesion volume u003c37 ml was similarly powerful with a 90% sensitivity and a low false positive rate. Other imaging markers derived from CT scans were less effective, but may be more practical. Published reports of over 600 LVO ischemic stroke patients disclosed that about half met the highly favorable IGR criteria of u003c5.4 ml/hr at presentation.Conclusions: Ischemic core initial growth rates of u003c5.4ml/hr and initial ischemic cores of u003c37 ml are excellent biomarkers for selecting LVO patients that are likely to benefit from intervention despite long delays due to transfer to thrombectomy-capable stroke centers. Published accounts suggest that about half of all LVO stroke patients meet these criteria.Clinical Trial Registration ID #NCT00414726.
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