Clinical Outcomes Using Mycophenolate And Tacrolimus For Graft Versus Host Disease Prophylaxis In Patients Undergoing Allogenic Stem Cell Transplant: A Single Institution Experience

Introduction: Graft versus host disease [GVHD] remains the major factor underlying transplant related morbidity and mortality among recipients of allogeneic stem cell transplant [allo-SCT]. The choice of GVHD prophylaxis is largely determined by HLA disparity between the donor and the recipient and the intensity of the conditioning regimen. Mycophenolate mofetil [MMF] plus calcineurin inhibitor [CNI] combination is mostly used in reduced intensity [RI] and non-myeloablative conditioning [NMAC] whereas methotrexate and CNI combination is preferred in myeloablative conditioning [MAC]. We present single institution outcomes in patients undergoing allo-SCT with MMF and CNI as the only combination for GVHD prophylaxis.