Socioeconomic Deprivation, Adverse Childhood Experiences and Medical Disorders in Adulthood: Mechanisms and Associations

    Molecular Neurobiology, pp. 5866-5890, 2019.

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    Keywords:
    Adverse childhood experiences Gene expression Hypothalamic–pituitary–adrenal axis Immune system MitochondriaMore(1+)

    Abstract:

    Severe socioeconomic deprivation (SED) and adverse childhood experiences (ACE) are significantly associated with the development in adulthood of (i) enhanced inflammatory status and/or hypothalamic–pituitary–adrenal (HPA) axis dysfunction and (ii) neurological, neuroprogressive, inflammatory and autoimmune diseases. The mechanisms by whic...More

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