First Trimester Pm2.5 Exposure Contributes To Adult Cardiac Dysfunction In Offspring

Introduction: PM2.5 exposure during entire in utero period is associated with adverse cardiovascular outcomes at adulthood. Hypothesis: We hypothesize that PM2.5 exposure can exert different cardiac cellular and functional effects during different trimesters. Here we investigate the effects of PM2.5exposure during the first trimester in utero on adult cardiac function in offspring. Methods: Female FVB mice were exposed either to filtered air (FA) or concentrated particulate matter (PM2.5) at a daily average concentration of 36.30 μg/m3 from the Columbus, OH region for 6 h/day for 7 days (length of first trimester of pregnancy). We examine cardiac function of male offspring at 12 weeks of via baseline echocardiographic assessment. Following sacrifice, cardiomyocytes were isolated to assess contractile functions. Protein isolated from LV tissue from separate groups of mice was used to study underlying mechanisms. Results: Adult mice exposed to PM2.5 during the first trimester demonstrated increased LVESd (2...