THE ADMINISTRATION OF TRICHURIS SUIS OVA EXTRACT DECREASES IL-17/IL-23 LEVELS IN EXPERIMENTAL INFLAMMATORY BOWEL DISEASE

This study investigated the anti-inflammatory effect of Trichuris suis ova extract (TSOE) on four cytokine biomarkers (IL-17, IL-23, IL-6 and IL-10) and on oxidative stress (erythrocyte superoxide dismutase - SOD and whole blood glutathione peroxidase - GPx). The inflammatory bowel disease (IBD) murine model was induced in rats with dextran sulphate sodium (DSS). The experiment was performed on 20 male Wistar rats. Group 1 - control group (CG) received only water; in groups 2 (DSS2), 3 (DSS3) and 4 (DSS4), 3% DSS was administered. The groups 3 and 4 received 100 mu g TSOE respectively 200 mu g TSOE. The mean level of IL- 23 was significantly higher in the DSS2 group compared to the CG (0.43 pg/mL vs 0.023 pg/mL). After TSOE treatment, the IL-23 concentration was higher in the DSS2 group compared to the DSS3 and DSS4 groups (0.43 vs 0.06 and 0.08 pg/mL, respectively). IL-23 was also paralleled by a decrease in the IL-17 mean level, but without statistical significance (Brown-Forsythe test, F (6; 4.34) = 2.54, p = 0.182). TSOE reduced IL-17/IL-23 levels in the DSS- induced IBD experimental model.