Structural modification, fungicidal and insecticidal activity of 5-arylbenzofuran neolignan from Magnolia officinalis

Ding Lin,Zhongzhong Yan,Yangjie Yi,Kangming Li,Jiao Ye,Aixi Hu,Chuyun Long,Aiping Liu

Phytochemistry Letters（2019）

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摘要

•5-Arylbenzofuran neolignan (1) was semi-synthesized from honokiol in a high yield.•Twenty-four 5-arylbenzofuran neolignan derivatives were synthesized.•Several derivatives displayed potent fungicidal and insecticidal activity.•Promising compounds showed low toxicity in the model of human cells.

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关键词

5-Arylbenzofuran neolignan,Fungicidal,Insecticidal,Structural optimization,Structure-activity relationship

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