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Preclinical development of the PI3K Alpha selective and PIK3CA Mutant selective inhibitor GDC-0077 and prediction of its human pharmacokinetics

Jodie Pang,Matthew Baumgardner,Marie-Gabrielle Braun,Jonathan Cheong,Kyle Edgar,Lori Friedman,Emily Hanan,Allan Jaochico,Shuguang Ma,Emile Plise,Stephen Schmidt,Ning Liu,Kyung Song, Steve Staben,Laurent Salphati

DRUG METABOLISM AND PHARMACOKINETICS（2019）

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human pharmacokinetics,pi3k,pik3ca
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