On-Demand Prolongation of Peripheral Nerve Blockade through Bupivacaine-Loaded Hydrogels with Suitable Residence Periods

Peripheral nerve blockade is an important perioperative intervention for pain management. However, this management always results in a limited analgesia effect due to the rapid elimination of local anesthetic drugs after a single injection, while continuous infusion leads to multiple side effects associated with catheter insertion. In this study, three thermosensitive hydrogels, i.e., Pluronic F127, and poly(l-alanine)-block-poly(ethylene glycol)-block-poly(l-alanine) (PAla-PEG-PAla), and poly(lactic-co-glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic-co-glycolic acid) (PLGA-PEG-PLGA), with distinct properties were applied to encapsulate bupivacaine (BUP) for prolonged analgesia with one single injection. All three hydrogel platforms exhibited a homogeneous three-dimensional structure with thermosensitive properties and high BUP encapsulation efficiency. The BUP loaded in PAla-PEG-PAla showed a sustained drug release profile, which was advantageous over those from Pluronic F127 and PLGA-PEG-PL...