Clinical Intererest Of High Frequency Transient Elastography To Assess Dermis Fibrosis In Patients With Venous Insufficiency

Transient elastography (TE) is a technique used to quantify Young's Modulus (E) by estimating shear wave velocity in homogenous tissues. This technique has been successfully integrated in the Fibroscan device to assess fibrosis stages in liver but has never been validated in the monitoring of skin fibrosis diseases. A specific device based on high-frequency transient elastography (HF-TE) is used to evaluate its performance in case of chronic venous disorder (CVD) diagnosis. E, dermis thickness (DT) and a new parameter, PE-DT, based on a logistic regression model using both E and DT are measured in the dermis of 48 healthy and 48 CVD patients. The discriminant capacity of E-DT and PE-DT parameters is evaluated with a receiver operating characteristic (ROC) analysis.