Abstract 18924: Porcine Model of Aortic Coarctation: Treatment With Novel Biodegradable Stent Up to 12mm Diameter

Introduction: A novel double opposing helical (DH) biodegradable stent (BDS) made of poly-l-lactic-acid can be fabricated to larger diameters needed for use in congenital heart disease. Study aims were: 1. Create a model of coarctation of aorta (CoA) in minipigs. 2. Evaluate feasibility of stent implantation (DH BDS and metal) and assess mid-term results and inflammatory profile. Hypothesis: DH BDS will maintain structural integrity to treat porcine CoA. Methods: Via left lateral thoracotomy, CoA was created in 7 Yucatan minipigs (7-9 kg) by resecting a portion of the aortic wall. Stents were implanted 6-8 weeks later. Assessment included: angiography, intravascular ultrasound and histopathology. Results: All 7 animals survived the CoA creation surgery and underwent successful stent implantation (4 DH BDS and 3 metal) via carotid (5) and femoral (2) access. 1 planned non-survival animal underwent a 10-mm metal stent implantation that successfully relieved the CoA. The remaining 6 minipigs underwent succes...