Molecular evolution of uncoupling proteins and implications for brain function

Neuroscience Letters（2019）

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摘要

•Proto-UCP1 plays an undefined role in brain function of ectothermic vertebrates.•Phylogenetic delineation excludes so-called UCP4 and UCP5 from the core UCP family.•Phylogenetic inference suggests no thermogenic evolution for UCP2 and UCP3 as found for UCP1.•The role of UCP2 in the brain is important but undefined.

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关键词

UCP,BAT,NST,ATP,GDP,ANT,ROS,MATPs,MYA,4-HNE

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