Patterns of responses on the Montreal Cognitive Assessment in Parkinson’s Disease Associated Mild Cognitive Impairment (P1.044)

Objective: To determine whether patients with Parkinson’s-associated mild cognitive impairment (PD-MCI) exhibit particular patterns of responses on the Montreal Cognitive Assessment (MoCA) and what demographic and disease-related factors may influence those patterns. Background: Cognitive decline is a debilitating non-motor complication of PD that increases morbidity and care-giver burden, and is associated with poorer quality of life. The MoCA is validated for use in PD, and can be completed at a regular clinic assessment. Design/Methods: A total of 557 MoCA’s completed by 213 patients with PD-MCI (corrected total MoCA score 21) were included. Principal Component Analysis was performed to determine the patterns of responses that explained the majority of the variance. The subject-specific loadings on these patterns were assessed with ANOVA to identify the influences of demographic factors. Results: Three patterns explain 81% of the variance in MoCA responses of patients with PD-MCI. Pattern 1 loaded positively on the number of words in 1 minute, language total score, and negatively with Visuospatial total. It is influenced by rate of disease progression (p=0.047). Pattern 2 loaded positively on number of words in 1 minute, and negatively on Visuospatial total score, and Delayed Recall. This pattern was influenced by gender (p=0.04). Conversely, Pattern 3 loaded positively on attention total score, number of words in one minute, serial 7’s and loaded negatively on Visuospatial total score. This pattern was influenced by years education (p=0.009). Conclusions: The majority of PD-MCI patients fall into one of three patterns of responses on the MoCA. Scores on some components of the MoCA differed from the mean scores across multiple patterns, particularly Visuospatial/Executive total score and the number of words in one minute. These patterns are influenced by different demographic factors. Further research is needed to determine if these patterns of responses are predictive of a benign or pathological prognosis. Disclosure: Dr. Mackenzie has nothing to disclose. Dr. Sundvick has nothing to disclose. Dr. Cai has nothing to disclose. Dr. Wile has nothing to disclose. Dr. Book has nothing to disclose. Dr. Wang has nothing to disclose. Dr. McKeown has nothing to disclose. Dr. Cresswell has nothing to disclose.