Extrapolating novel techniques utilised in solid organ transplantation to the microsurgical and vascularised composite allograft arena
Journal of Plastic, Reconstructive & Aesthetic Surgery(2019)
摘要
Ischemia reperfusion injury (IRI) is characterised initially by restriction of oxygenated blood flow to an organ bed, resulting in tissue hypoxia and ischaemic injury, followed by further 'reperfusion' injury upon restoration of perfusion, with an influx of oxygen, inflammatory cells and generation of free radicals. The culmination is a complex interplay between cellular and biochemical processes involved in inflammation and coagulation, exhibited as the 'no re-flow' phenomenon.
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关键词
solid organ transplantation
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