Neuroprotective effect of Sanqi Tongshuan Tablets on sequelae post-stroke in rats

Abstract Objective To identify the therapeutic effect and possible mechanisms of Chinese medicine Sanqi Tongshuan Tablets (SQTS) on sequelae post-stroke in rats. Methods The rat cerebral ischemia sequelae post-stroke models were successfully induced by blocking the middle cerebral artery with electric coagulator after the seventh week and balance beam test ≤ 4. The rats were then received with SQTS (0.5, 1, and 2 g/kg) and Naodesheng (NDS, 1.24 g/kg), Vinpocetine (VP, 1.55 mg/kg) for 30 d. The beam-walking test and shuttle test were performed before and after 10, 20, and 30 d of administration. In addition, histopathology changes and GAP-43, GFAP were measured by HE Decreased electric shock by 35.0% ( P  u003e 0.05), 50.0% ( P  u003e 0.05), and 75.0% ( P Conclusion SQTS showed therapeutic benefits on sequelae post-stroke in rats, which might be through the pathway of regeneration or neuroplasticity.