Cytotoxicity and antioxidant activity of Kamolonol acetate from Ferula pseudalliacea, and studying its interactions with calf thymus DNA (ct-DNA) and human serum albumin (HSA) by spectroscopic and molecular docking techniques

Process Biochemistry(2019)

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摘要
•Kamolonol acetate (KamA) was extracted from plant of Ferula pseudalliacea.•Cytotoxic effect of KamA on cancer cells was more than those normal cells.•A strong antioxidant activity was shown by KamA on DPPH radicals (EC50 = 65.29 μM).•Binding mechanism between DNA and KamA was an intercalative mode.•Through a static quenching mode (2.22 nm), KamA binds within subdomain IIA of HSA.
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关键词
Anticancer activity,DPPH radicals,Fluorescence lifetime,DNA intercalation binding mode,Circular dichroism
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