Multi-Well Sensor Platform Based on a Partially Etched Structure of a Light-Addressable Potentiometric Sensor

A multi-well-structured light-addressable potentiometric sensor (LAPS) plate is developed for measuring a plurality of sample solutions on a single sensor plate. It is also capable of high-resolution chemical imaging inside the well structure. It can be applied, for example, to quantification of metabolic activities and imaging of biological samples incubated in the well structure. A minimum pattern size of 20 mu m line is visualized and a wider frequency bandwidth of up to 200 kHz for the sensor signal is obtained in the well structure, which will be suitable for recording chemical images at a high-frame-rate.