Abstract 13698: Does Obesity Impact Left Ventricular Thickness in Children With Hypertrophic Cardiomyopathy?

Introduction: Hypertrophic cardiomyopathy (HCM) is a genetic heart disease with diverse natural history. The hallmark of HCM is severe left ventricular hypertrophy (LVH). In adults with HCM, obesity additionally increases LVH. It is not known whether obesity can lead to further LVH in children with HCM. Hypothesis: Obesity is associated with additional LVH in children with HCM. Methods: Echocardiogaphic LV dimensions were determined from 2D and/or M-mode images according to established criteria in 593 children ≥2 and ≤20 years of age with phenotypic sarcomeric HCM. Children with HCM associated with syndromes and storage disorders were excluded. Genotype-positive, phenotype-negative patients were excluded. Echocardiographic measurements of interventricular septal thickness (IVST) and posterior wall thickness (PWT), and patients’ weight and height at the time of the echo were collected. Obesity was defined as a body mass index (BMI) ≥95th percentile for age and sex, as defined by CDC guidelines. IVST data w...