Stereoselective synthesis of secondary and tertiary propargylic alcohols induced by a chiral sulfoxide auxiliary

Tetrahedron Letters(2019)

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摘要
•This method is possible to obtain a chiral propargylic alcohols which is important as a synthetic intermediate.•Stereoselective alkynylation accomplished without additives.•Aldehyde as well as ketone can be used as a substrate.•Desulfurization was achieved with mild condition.•Chiral propargylic alcohol with various substituents was synthesized.
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关键词
Alkynylation,Chiral sulfoxide,Diastereoselectivity,Lithium acetylide
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