Probing epithelial tissue rheology with a Stokes experiment
arXiv: Tissues and Organs(2018)
摘要
We perform a bidimensional Stokes experiment in an active cellular material: we force a monolayer of Madin-Darby Canine Kidney (MDCK) epithelial cells to migrate around a circular obstacle within a long and narrow channel, involving cell shape changes and neighbour rearrangements. Based on image analysis of tissue flow velocity and cell shape, we determine the tissue strain rate, cell deformation and cell rearrangement rate fields, which are spatially heterogeneous. We find that the cell deformation and cell rearrangement rate fields correlate strongly, which is compatible with a viscoelastic liquid behaviour with a relaxation time $tau = 70pm 15$ min. In our experiment, the monolayer behaves as a flowing material with a Weissenberg number close to one which shows that both elastic and viscous effects can have comparable contributions in the process of collective cell migration.
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