Blood levels of nitric oxide and DNA breaks assayed in whole blood and isolated peripheral blood mononucleated cells in patients with multiple sclerosis

Vitālijs Borisovs,Elīna Ļeonova,Larisa Baumane,Jolanta Kalniņa, Natalja Mjagkova,Nikolajs Sjakste

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2019）

引用 11|浏览10

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摘要

•Patients with MS have elevated level of DNA damage.•Comet assay of whole blood and lymphocytes showed similar results in MS patients and control group.•Patients with MS have significantly higher level of NO in the blood.•Data from the comet assay and EPR follow the same trend.

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关键词

Comet assay,Electron paramagnetic resonance spectroscopy,DNA damage,Magnetic resonance spectroscopy,Magnetic resonance imaging,Relapse-remitting multiple sclerosis

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