Predicting Potential Targets Of Mir-130a In Venous Thromboembolism Based On A Target Score Method

This paper proposed to predict potential targets of miR-130a in venous thromboembolism (VTE) utilizing a TargetScore method, and to further uncover the junctions of miR-130a in VTE. miRNA-overexpression data were collected and log Fold Change(logFC) value was computed for every gene in the dataset. Subsequently, sequence scores were calculated based on Variational Bayesian-Gaussian Mixture Model and Variational Bayesian Expectation-Maximization algorithm. Ultimately, the target score between miR-130a and each gene was counted by integrating the logFC and sequence scores, to investigate potential targets for miR-130a. Based on the targets, pathway enrichment analysis was conducted to explore significant gene sets in VTE patients. 225 potential targets in VTE were predicted for miR-130a, and 16 significant pathways with P 更多