Increased Pulmonary-Systemic Pressure Ratio Is Associated With Adverse Events In Advanced Heart Failure

Increased Pulmonary-Systemic Pressure Ratio is Associated with Adverse Events in Advanced Heart Failure: Introduction: Concomitant presence of pulmonary hypertension in heart failure (HF) is associated with increased adverse events and may be related to interventricular uncoupling and impaired cardiac efficiency. Hypothesis: In patients treated for acute decompensated HF, an increased mean pulmonary artery pressure (MPAP) to mean arterial pressure (MAP) ratio (MPS ratio) would be associated with worse clinical outcomes. Methods: Using Cox proportional hazards regression analysis of patients enrolled in the ESCAPE (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness) trial, we evaluated associations between the MPS ratio at discharge and clinical outcomes, including time to death, transplant or left ventricular assist device [LVAD], (DTxLVAD) and time to death, transplant, LVAD or heart failure rehospitalization (DTxLVADHF) over 6 months. Results: Among 162 patie...