Presence of thrombophilia and levels of coagulation factors, coagulation inhibitors and TAFI do not affect global haemostasis or bleeding phenotype in patients with haemophilia A

•Proteins C and S explain part of OHP and ETP posttreatment values in haemophilia A.•Thrombophilia does not protect against a severe bleeding phenotype.•The prevalence of thrombophilia in haemophilia A patients is similar to controls.•OHP and ETP were not affected by coagulation factors and TAFI.