Fibrinolytic enzyme production from low-cost substrates by marine Bacillus subtilis: Process optimization and kinetic modeling

Shihan Pan,Guiguang Chen,Jingjing Zeng,Xiaoyan Cao, Xin Zheng,Wei Zeng,Zhiqun Liang

Biochemical Engineering Journal（2019）

引用 20|浏览5

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摘要

•A low-cost medium containing soybean meal was designed.•The fermentation process was successfully scaled up in 100 L pilot fermenter.•Kinetic models were established for fermentation with different oxygen supply.

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关键词

Bacillus subtilis,Fibrinolytic enzyme,Process optimization,Oxygen supply,Kinetics

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