Mapping Of The Angiotensin At2 Receptor-Coupled Signalling Network By Time-Resolved Quantitative Phosphoproteomics In Human Aortic Endothelial Cells Identified Hdac-1 And P53 To Be Involved In At2 Receptor-Mediated Anti-Proliferation

Ulrike Muscha Steckelings,Antonio Augusto Bastos Peluso,Stefan J. Kempf,Thiago Verano Brega,Michael Bader,Martin R. Larsen,Robson A.s. Santos

JOURNAL OF HYPERTENSION（2018）

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摘要

Objectives:The angiotensin AT2-receptor (AT2R) is a main component of the protective arm of the renin-angiotensin system. In order to get new and deeper insights into AT2R mediated signalling, this study mapped the AT2R-coupled phosphoproteome in human aortic endothelial cells (HAEC) by quantitative

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关键词

angiotensin, AT2-receptor, phosphoproteomics, signaling, proliferation, apoptosis

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