A4190 Relationship between plasma N-terminal pro-atrial natriuretic peptide and Corin levels and disease severity in patients with pregnancy induced hypertension

Objectives: We investigate the plasma N-terminal atrial natriuretic peptide (NT-proANP) and corin in pregnancy induced hypertension (PIH) and studies the correlation between plasma NT-proANP/ corin levels and adverse events. Methods: A total of 77 PIH who admitted in hospital were enrolled. 48 normotensive pregnancies in the same gestational weeks were chosen as control. Clinical characteristics were collected. Plasma was collected for laboratory examination Results: NT-proANP and corin was significantly increased in PIH compared with control (P = 0.003 and P < 0.001). The association between plasma NT-proANP/corin and the adverse event demostrated that 1) In PIH, NT-proANP and corin were increased significantly in preterm compared with that in full-term birth (P < 0.001 and P = 0.023); 2) Weeks of gestation in PIH patients were dramatically reduced compared with control, and it was negative correlated to NT-proANP and corin (R = −0.487, P < 0.001 and R = −0.383, P = 0.000); 3) The weight of newborns in PIH was significantly lower than that in control, and it was negatively correlated with NT-proANP and corin (R = −0.487, P < 0.001 and R = −0.383, P = 0.001); 4) The APGARP score of PIH was significantly lower than that of control, and it was negatively correlated with NT-proANP (R = −0.359, P = 0.001). NT-proANP/Corin and target organ function demonstrated that 1) The eGFR of PIH was significantly lower than that of control (P < 0.001), and it was negatively correlated with NT-proANP and corin (R = −0.490, P < 0.001 and R = −0.415, P < 0.001); 2) The urinary protein in PIH was significantly increased than that in control (P < 0.001), and it was positively correlated with NT-proANP and corin (R = 0.386, P = 0.001 and R = 0.401, P < 0.001). Conclusion: The plasma NT-proANP and corin was increased in PIH, and both of them may associate with the severity of PIH.