Disease Status Affects The Association Between Rs4813620 And The Expression Of Alzheimer'S Disease Susceptibility Gene Trib3

Lorenzi et al. (1) recently applied a functional prioritization method to the Alzheimer’s Disease Neuroimaging Initiative dataset and successfully identified a link between tribbles pseudokinase 3 ( TRIB3 ) and the stereotypical pattern of gray matter loss in Alzheimer’s disease (AD). Lorenzi et al. conducted an expression quantitative trait loci (eQTL) analysis using the dataset from the Genotype Tissue Expression (GTEx) project and found that rs4813620 was the top eQTL variant for TRIB3 . The rs4813620 variant and its proxy, rs62191440 ( D ′ = 0.8469; r 2 = 0.6559), could regulate the expression of TRIB3 in various tissues, including the nervous tissue proxy nerve tibial, as well as two brain tissues, the cortex and the caudate ganglia.It is reported that disease status may have significant effects on gene expression (2⇓– … [↵][1]1To whom correspondence should be addressed. Email: qhjiang{at}hit.edu.cn. [1]: #xref-corresp-1-1