Synthesis of a unique dimethyl thiazoline containing intermediate of novel peroxisome proliferator-activated receptors(PPAR)δ agonists

Tara Man Kadayat,Geumwoo Lee,Kyungjin Jung,Hee-Jong Hwang,Jeongmin Joo,Dongyup Hahn,Hayoung Hwang,Keun-Gyu Park,Sung Jin Cho,Kyung-Hee Kim,Jungwook Chin

Tetrahedron Letters（2018）

引用 3|浏览15

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摘要

•Method for unique dimethyl thiazoline containing intermediate of PPARδ agonists.•TBAHS as catalyst for efficient coupling of 11 with 12.•Potential use of intermediate 13 for synthesis of novel PPARδ-selective agonists.

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关键词

GW501516,TBAHS catalyst,d-Penicillamine,4-Mercapto-2-methylphenol,PPAR agonists

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