THE BDNF VAL66MET SNP IS RELATED TO HIPPOCAMPAL CONNECTIVITY AND COGNITIVE DECLINE IN AUTOSOMAL DOMINANT ALZHEIMER’S DISEASE

p1⁄4.02-.03 respectively, Fig.2A). Furthermore, higher scores on this personality/NPF component were associated with worse immediate memory (F1,701⁄44.1, p1⁄4.05, Fig.2B), regardless of Ab status. Conclusions: Our multivariate approach revealed that Ab burden was increased in cognitively normal individuals at risk of AD showing high levels of perseverative thinking, neuroticism and apathy, which were in turn related to altered brain connectivity and lower cognition. Overall, these results highlight the importance of personality/NPF burden on early AD pathophysiology.