Maternal Antibiotic Use During Pregnancy And Type 1 Diabetes In Children-A National Prospective Cohort Study
DIABETES CARE(2018)
摘要
Prenatal prescription of antibiotics is common but may perturb the composition of the intestinal microbiota in the offspring. In childhood the latter may alter the developing immune system to affect the pathogenesis of type 1 diabetes (1). Previous epidemiological studies reported conflicting results regarding the association between early exposure to antibiotics and childhood type 1 diabetes (2,3). Here we investigated the association in a Danish register setting.The Danish National Birth Cohort (DNBC) provided data from 100,418 pregnant women recruited between 1996 and 2002 and their children born between 1997 and 2003 ( n = 96,840). The women provided information on exposures during and after pregnancy. Antibiotic prescription during pregnancy was obtained from the Danish National Prescription Registry (anatomical therapeutic chemical code J01), and type 1 diabetes diagnoses (diagnostic codes DE10 and DE14) during childhood and adolescence were obtained from the Danish National Patient Register. The children were followed until 2014 (mean follow-up time 14.3 years [range 11.5–18.4 years, SD 1.4]). We excluded ( n = 4,828) twins and triplets, children born before gestational week 26, children weighing u003c500 g at birth, and stillbirths, leaving 92,012 children for unadjusted analyses. Socioeconomic status, parity, maternal diabetes, smoking …
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关键词
antibiotic,diabetes,pregnancy,national prospective cohort study
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