Disturbances of sleep quality, timing and structure and their relationship with other neuropsychiatric symptoms in Alzheimer’s disease and schizophrenia: Insights from studies in patient populations and animal models

Neuroscience & Biobehavioral Reviews(2019)

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摘要
•Sleep disturbances are common in Alzheimer’s disease and schizophrenia.•Sleep disturbances can precede Alzheimer’s disease and schizophrenia.•Some sleep disturbances associate with neuropsychiatric symptoms.•Preclinical models can provide insights into mechanisms linking sleep and symptoms.•Standardising methods across disorders aids understanding sleep-symptom relations.
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关键词
Amyloid clearance,Animal models,Apathy,Circadian,Cognition,PRISM,REM sleep,Sleep fragmentation,Social withdrawal,Spindles,rTg4510,Transgenic models
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