FXR activation normalizes dyslipidemia and alleviates obesity in western-type diet–fed APOE*3-Leiden.CETP transgenic mice

Y. Paalvast,E. Zhou, N. L. Mulder,M. Koehorst,R. Boverhof,K. Willems van Dijk,P. C. N. Rensen,J. A. Kuivenhoven, C. Kremoser,Y. Wang,F. Kuipers,A. K. Groen,J. F. de Boer

Atherosclerosis（2018）

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摘要

Aim: Pharmacological stimulation of the bile acid-activated nuclear receptor FXR has been demonstrated to improve non-alcoholic steatohepatitis. However, the effects of FXR activation on other aspects of the metabolic syndrome, including hyperlipidemia, are incompletely understood. Therefore, we assessed the effects of FXR stimulation in a mouse model with humanized lipoprotein metabolism.

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关键词

apoe*3-leidencetp transgenic mice,fxr activation,transgenic mice,obesity,diet–fed,western-type

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