Patients with Type 2 Diabetes (T2D) on the Maximum Dose of Insulin Degludec/Liraglutide (IDegLira) Achieve Glycemic Target—Analyses from the DUAL Program

The efficacy and safety of IDegLira has been established in the DUAL clinical development program. This post-hoc analysis evaluated glycemic control in the subgroup of patients titrated to the maximum approved IDegLira dose of 50 units (U) (50 U insulin degludec + 1.8 mg liraglutide), from trials that evaluated IDegLira vs. other comparators (DUAL I-V and VII). In all DUAL trials, baseline A1C was similar between IDegLira and comparator arms. In DUAL I-V, regardless of end-of-trial (EOT) doses (50 or For patients at 50 U and In conclusion, a high proportion of patients receiving the maximum approved dose of IDegLira are able to achieve good glycemic control. Disclosure L. Meneghini: Advisory Panel; Self; Novo Nordisk Inc., Sanofi US. Consultant; Self; Sanofi US, Novo Nordisk Inc.. Advisory Panel; Self; Intarcia Therapeutics, Inc.. Other Relationship; Self; American Diabetes Association. S. Linjawi: Advisory Panel; Self; Novo Nordisk A/S, Eli Lilly and Company, Sanofi. Research Support; Self; Novo Nordisk A/S, Boehringer Ingelheim GmbH, AstraZeneca, Eli Lilly and Company, Lexicon Pharmaceuticals, Inc.. Speaker9s Bureau; Self; Novo Nordisk A/S, Eli Lilly and Company, Sanofi. P. Serusclat: Board Member; Self; Novo Nordisk A/S, Medtronic, Abbott. Research Support; Self; Novo Nordisk A/S, Eli Lilly and Company, Sanofi. T. Vilsboll: Advisory Panel; Self; Amgen Inc., Boehringer Ingelheim GmbH, Eli Lilly and Company, AstraZeneca, MSD K.K., Sanofi, Novo Nordisk A/S. Consultant; Self; Amgen Inc., Boehringer Ingelheim GmbH, Eli Lilly and Company, AstraZeneca, MSD K.K., Sanofi, Novo Nordisk A/S. Speaker9s Bureau; Self; Amgen Inc., Boehringer Ingelheim GmbH, Eli Lilly and Company, AstraZeneca, MSD K.K., Sanofi, Novo Nordisk A/S. Research Support; Self; Eli Lilly and Company, Novo Nordisk A/S. B.F. Agner: Employee; Self; Novo Nordisk A/S. T. Hansen: Employee; Self; Novo Nordisk A/S. L.A. Leiter: Advisory Panel; Self; AstraZeneca. Research Support; Self; AstraZeneca. Speaker9s Bureau; Self; AstraZeneca. Advisory Panel; Self; Boehringer Ingelheim Pharmaceuticals, Inc.. Research Support; Self; Boehringer Ingelheim Pharmaceuticals, Inc.. Speaker9s Bureau; Self; Boehringer Ingelheim Pharmaceuticals, Inc.. Advisory Panel; Self; Eli Lilly and Company. Speaker9s Bureau; Self; Eli Lilly and Company. Research Support; Self; GlaxoSmithKline plc.. Advisory Panel; Self; Janssen Pharmaceuticals, Inc.. Research Support; Self; Janssen Pharmaceuticals, Inc.. Speaker9s Bureau; Self; Janssen Pharmaceuticals, Inc.. Advisory Panel; Self; Merck u0026 Co., Inc.. Speaker9s Bureau; Self; Merck u0026 Co., Inc.. Research Support; Self; Merck u0026 Co., Inc.. Advisory Panel; Self; Novo Nordisk Inc.. Research Support; Self; Novo Nordisk Inc.. Speaker9s Bureau; Self; Novo Nordisk Inc.. Advisory Panel; Self; Sanofi. Research Support; Self; Sanofi. Speaker9s Bureau; Self; Sanofi. Advisory Panel; Self; Servier. Speaker9s Bureau; Self; Servier. Research Support; Self; Servier. Advisory Panel; Self; Amgen Inc.. Speaker9s Bureau; Self; Amgen Inc.. Research Support; Self; Amgen Inc., Esperion Therapeutics, Kowa Pharmaceuticals America, Inc., The Medicines Company. Advisory Panel; Self; Akcea Therapeutics, Novartis Pharmaceuticals Corporation.