An Efficient and Straightforward Total Synthesis of (±)-Preclamol

LETTERS IN ORGANIC CHEMISTRY（2018）

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摘要

A prudent and scalable synthesis of (+/-)-Preclamol is described utilizing Michael addition and in-situ reduction/cyclization of an aryl-alpha-carbethoxy acetonitrile derivative as a key step.

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关键词

Michael addition,in-situ reduction/cyclization,preclamol,risperidone,alogliptin,ritalin

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