First total synthesis of cyclic pentadepsipeptides Hikiamides A–C

Donglin Fu,Xuemin Rao,Jinyi Xu,Genzoh Tanabe,Osamu Muraoka,Xiaoming Wu,Weijia Xie

Tetrahedron Letters（2018）

引用 3|浏览10

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摘要

•First total syntheses of natural cyclodepsipeptides Hikiamides A–C are described.•Solid-phase peptide synthesis was found effective to assemble linear pentapeptides.•Cyclization of linear pentapeptides in solution phase provided Hikiamides A–C.

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关键词

Total synthesis,Hikiamides A–C,Fusarium sp.,Solid-phase peptide synthesis

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