Total Synthesis Of (-)-Nahuoic Acid C-I (B-Ii)

A convergent total synthesis of (-)-nahuoic acid C-i(B-ii) (3), a novel cis-decalin polyketide, has been achieved. Key synthetic transformations include Type II Anion Relay Chemistry (ARC) to construct the polyol chain, a Ti-catalyzed asymmetric DielsAlder reaction to generate the cis-decalin skeleton, and a late-stage large fragment union exploiting a Micalizio alkoxide-directed alkynealkene coupling tactic.