Asymmetric Organocatalytic Cascade Synthesis of Tetrahydrofuranyl Spirooxindoles
SYNTHESIS-STUTTGART(2018)
摘要
An enantio- and regioselective organocatalytic cascade starting from isatin has been disclosed to construct tetrahydrofuranyl spirooxindoles in high yields and stereoselectivities. Also, a triple cascade leading to the pentacyclic compound with two quaternary and a tertiary stereocenter is described. The reactions were catalyzed by cinchonine-based thiourea.
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关键词
organocatalysis,domino reaction,enantioselectivity,heterocycles,Michael addition
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