Salivary Duct Carcinoma: Clinical Outcomes And Prognostic Factors In 157 Patients And Results Of Androgen Deprivation Therapy In Recurrent Disease (N=31)-Study Of The Dutch Head And Neck Society ( Dhns).

6016Background: Salivary Duct Carcinoma (SDC) is a rare, highly aggressive subtype of salivary gland cancer, which is androgen receptor (AR) positive in most pts. In recurrent disease androgen deprivation therapy (ADT) can be used, however only limited data are available. The aim of this study was to evaluate clinical outcome, to identify prognostic factors for overall survival (OS) and to retrospectively analyze efficacy of ADT. Methods: The nationwide network and registry of histo- and cytopathology (PALGA) identified all adult pts with SDC between 1990 - 2014 in the Netherlands. Lymph node ratio (LNR) was defined as the number of positive LN divided by the total number of LN after neck dissection. Survival analyses were conducted using Kaplan-Meier method. The Cox proportional hazard model was used to identify prognostic factors on uni- and multivariable analyses. Results: A total of 157 pts with SDC were identified. Median age was 66 years, 77% were male. AR and HER2neu were positive in 100% and 44%, ...