An Efficient and Green Synthesis of 1′Hspiro[isoindoline-1,2′-quinazoline]-3,4′(3′H)-dione Derivatives in the Presence of Nano Fe3O4–GO–SO3H

In this article a simple, rapid, green and efficient method for the synthesis of various 1?Hspiro[isoindoline-1,2?-quinazoline]-3,4?(3?H)-diones in the presence of acidic magnetic graphene oxide nanosheets (Fe3O4?GO?SO3H) as catalyst is reported. Different substituted spirooxindoles have been synthesized from one-pot three component reaction of isatoic anhydride, aliphatic or aromatic primary amines and isatin in the presence of Fe3O4?GO?SO3H. This reaction allowed us to prepare some new and known derivatives of substituted spirooxindoles. The worthwhile advantages of this method are high product yields, short reaction times, the possibility of using of a magnetic, reusable and non-toxic catalyst and solvent-free conditions.